High levels of saturated fatty acids, which can be found in the ovaries of obese women and women suffering from type 2 diabetes can prevent the development of the embryo and lead to an unsuccessful pregnancy.
This may explain why women with metabolic disorders can not conceive normally, according to an article published in the journal PLoS ONE. Researchers found: people in this group tend to absorb more risk of being stored in body fat. As a result, increases the level of saturated fatty acids in the ovaries. And they have a toxic effect on the developing oocyte before ovulation, says the head of research Professor Joe Leroy from the University of Antwerp.
It turned out embryos with a less active metabolism are more likely to result in normal pregnancies. A high level of saturated fatty acids increased the metabolism of amino acids, altered oxygen consumption, glucose and lactate. Moreover, although the fatty acids do not interfere with the egg to develop two-celled stage, their number who reach the level of blastocysts significantly decreased.
